19 December 2014
$1m to fund new Ebola test
Point-of-care device set to overcome many of today’s Ebola diagnosis challenges
Product design and development firm Cambridge Consultants is working with non-profit enterprise Diagnostics For All to develop a low-cost point-of-care device for testing patients for the Ebola virus. The project is being funded with a $1m challenge grant from Massachusetts Life Sciences Center, which supports innovation-driven economic development initiatives. The goal of the project is to develop a device – within months rather than years – that is simple to use and delivers results quickly, in areas where there may be little or no access to medical facilities or trained doctors, nurses and lab technicians to administer the tests.
Diagnosing Ebola, from a logistical perspective, is extremely challenging. Particularly in rural areas, it is a challenge to get patients to a clinic to have their blood drawn – and it must then be transferred to a lab and tested on specialty instrumentation by trained technicians. When results are obtained, health workers must then find the patient, who, if infected, could already be spreading the virus. Hours or days may pass between taking a blood sample and providing medical treatment.
With this new device, a minimally trained health worker will be able to administer and run the test, without a lab, and get results within an hour. What’s more, as a point-of-care device, potential patients don’t have to go to clinics – the test can be taken to them.
The device will be a handheld, single-use disposable device that is smaller than a deck of cards. It simply requires a health worker to prick a patient's finger and directly apply a droplet of blood on to the device. All aspects of the diagnostic assay are then fully integrated inside the device. The entire process will be completed in 45 minutes.
Marcus Lovell Smith, CEO of Diagnostics For All, said: “We are thrilled to be working with Cambridge Consultants on this, having collaborated on previous projects. This time we are racing to combat a deadly epidemic. When we wanted to dramatically accelerate this non-instrumented molecular diagnostic platform, we knew that Cambridge Consultants – with its extensive expertise in diagnostic product development – would be a key partner.”
David Chastain, programme manager at Cambridge Consultants, said: “Simple, low-cost testing tools that require minimal training to use are becoming essential in developing countries where the virus outbreak is most severe. The combination of our systems design, mechanical engineering and human factors skills with Diagnostics For All’s vision and expertise in molecular diagnostics can help transform the way that health workers provide point-of-care diagnosis – and subsequent treatment – in at-risk areas.”
The target cost for the new device – which is expected to be developed, produced and in field testing within six months – is less than $10 per cartridge.
Cambridge Consultants’ world-class engineering teams in Cambridge (UK), Boston (USA) and Singapore design and develop cutting-edge technology for the world’s leading companies and innovative start-ups. The firm has a 50-year track record of helping clients get breakthrough products to market fast – from the creation of concepts through to commercialisation. Its medical technology product development work includes diagnostic, surgical and drug delivery devices as well as digital health technologies.
Cambridge Consultants develops breakthrough products, creates and licenses intellectual property, and provides business consultancy in technology-critical issues for clients worldwide. For more than 50 years, the company has been helping its clients turn business opportunities into commercial successes, whether they are launching first-to-market products, entering new markets or expanding existing markets through the introduction of new technologies. With a team of more than 700 staff, including engineers, scientists, mathematicians and designers, in offices in Cambridge (UK), Boston (USA) and Singapore, Cambridge Consultants offers solutions across a diverse range of industries including medical technology, industrial and consumer products, digital health, oil and gas, and wireless communications.
Cambridge Consultants is part of Altran, a global leader in engineering and R&D services which offers its clients a new way to innovate. Altran works alongside its clients on every link in the value chain of their project, from conception to industrialisation. In 2015, the Altran group generated revenues of €1.945bn. With a headcount of more than 27,000 employees, Altran is present in more than 20 countries. For more information, visit www.altran.com.
Incorporated in 2007, Diagnostics For All is a non-profit enterprise creating low-cost, easy-to-use point-of-care diagnostic devices specifically designed for the developing world. These devices are elegantly simple and inexpensive. They require minimal training to use and minimal sample preparation, and no electricity or additional equipment. For more information, visit: www.dfa.org
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